CIP Spray Ball
Filter Housing Spray Devices
The increased use of larger multi-element filter housings in pharmaceutical and biotech processes has focused increased attention on replacement of removal and transport to an equipment cleaning area by application of CIP (Clean-In-Place) procedures. CIP, as part of the process CIP circuit, reduces the handling of the components, the possibility of damage, and improves operator safety. Effective CIP methodology must provide also for incorporating the associated piping and valves required for flushing, steaming, blow-down, integrity testing, filtration , and, of course, CIP operations.
ESC Filter Housing CIP Devices
Spray CIP of an 8 inch diameter filter housing requires only 5-6 Gpm and those of larger diameter require the normally accepted vessel spray flow rate applicable to vertical tanks; i.e., 2 Gpm/Foot of Circumference . . .
. An 8″ diameter housing would require approximately 4 Gpm.
. A 16 ” diameter housing would require approximately 8 Gpm.
. A 24″ housing would require approximately 12 Gpm.
However, the transfer piping system, rather than the filter housing diameter will determine the circuit flow rate.
Two different spray distribution devices have been created including a simple disc distributor that assures full coverage of filter housings of commonly used diameters at high flow rates and minimal pressure, and a spray tube that provides a controllable pattern more analogous to a fixed ball spray for use in filter housings fitted with auxiliary nozzles in the domes. Both sprays are fabricated of 316L St St, electro-polished, and designed and intended for permanent installation during all phases of the cleaning, steaming and filtration processes and have successfully passed riboflavin coverage tests in a variety of filter housings. Though simple in design and hydraulic function, the customization of either spray requires full knowledge of each filter housing inlet dimensions, the flow rate for the largest diameter piping in the circuit, and the downstream pressure and flow requirements.
Validatable CIP Cleaning of Filter Housings and Piping, in the Process CIP Circuit
The schematic at the right is representative of the typical design and engineering practices now in use. Transfer line piping of 1-1/2″ diameter requires a flow of 23-25 Gpm and 43-45 Gpm is required for 2″ size. All top piping connections for Venting, CA, CS and water (if required) should be located on the inlet manifold with minimum dead leg valves and thus be subjected to full CIP/SIP treatment with the housing. The filter inlet valve (1). the Vent Valve (3) and the Condensate Drain valves must be automated for control by CIP system software. The other valves may be air-operated or hand operated as they are open full time during the CIP program.
The CIP operation requires the passage of the minimum flow required for 5 FPS in the associated piping through the filter housing spray at all times, with air injected to the CIPS stream as required to keep the housing essentially empty. The filter inlet valve (1) would be opened for 3 – 5 seconds of each minute to clean the inlet connection, and the Vent valve (4) and Condensate Drain valves would be pulsed to waste to clean their passages.
A single filter, or multiple filters can be cleaned in combination with any process piping in which they are installed, and a filter may be installed in a transfer line to a vessel used also for vessel CIP. See the subsequent slide Filter Housing CIP Applications.